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In another study, researchers discovered that tirzepatide treatment, when combined with a decrease in circulating levels of branched-chain amino (BCAA) and keto (BCKA) acid metabolites linked to the development of systemic insulin resistance (IR) and T2DM improves insulin sensitivity in obese mice and humans with T2DM [82]

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Histological analysis of prostate biopsy from these patients reveals fibrous connective tissue, smooth muscle, and no identifiable epithelial tissue, suggesting atrophic epithelium or lack of epithelial differentiation 35